Three aspiring biophotonics entrepreneurs working on potentially life-saving techniques for detecting cancer and malaria have won some expert help in moving their ideas to market. As winners of a Biophotonics Startup Challenge at SPIE Photonics West in January, the three are being sponsored by Newport Spectra-Physics to attend the Biomedical Engineering Entrepreneurship Academy at the University of California, Davis, next summer. A cheek-swab test for lung cancer would be "a paradigm shift, in that we don't need to examine the tumor itself to determine the presence of cancer," said Hariharan Subramanian (Northwestern University) of the technique he and colleagues including Hemant Roy (North Shore University Health System) and Vadim Backman (Northwestern) have developed. Hariharan Subramanian describes for Biophotonics Startup Challenge judges the technology behind a cheek-swab test for lung cancer. A system based on total internal reflection principles that